Syllabus (ANTHROPOLOGY)

Course Type: MAJ-9

Semester: 6

Course Code: BANTMAJ09C

Course Title: Human Genetics

(L-P-Tu): 5-1-0

Credit: 6

Practical/Theory: Combined

Course Objective: To understand how genetic traits are inhered from one generation to the next To understand the chromosomal structure of human being. Molecular and cellular mechanisms of genetic diseases, including Mendelian disorders and rare diseases.

Learning Outcome: The students will learn about genetics and the principles of human genetics; the inheritance and the factors influencing inheritance; the role of admixture in population structure; and from the practical component they will learn about identifying colour

BANTMJ09C: Human Genetics 6 credits

Total Marks: 50 (30 theory + 20 practical)

Theory:

Unit- I. Essentials of Genetics: landmarks in the history of genetics, principles in human genetics, single locus (Mendelian) versus multilocus (quantitative/complex) inheritance, chromosome theory of inheritance (segregation and independent assortment).

Unit–II. Methods of studying human genetics, Cell division: mitosis and meiosis, Human Chromosomes and Karyotyping, chromosomal aberrations: structure and numerical - Cri-du-cat, Down Syndrome, Patau’s Syndrome, Turners syndrome, Klinefelter syndrome.

Unit-III. Concept of gene, allelomorph, heterozygote, homozygote, phenotype, genotype. Nucleic Acid: DNA and RNA -structure and function, DNA replication

Unit–IV. Mendelian inheritance (single factor and multifactorial inheritance, polygenic inheritance), non-Mendelian inheritance (multiple allelism, co-dominance, sex-linked, epistasis, penetrance and expressivity, Cytoplasmic inheritance).

Practical 20 marks

1. Red Green Colour Blindness Test
2. PTC tasting ability
3. Karyotyping (One normal male, One normal female, two different disorders of your choice)
4. Pedigree Analysis (Two genetic traits of your choice)

References

Jurmain, R., Kilgore, L., Trevathan, W., Ciochon, R.L. 2012. Introduction to Physical Anthropology. Wadsworth Publ.

Harrison, G.A., Tanner, J.M., Pibeam, D.R., Baker, P.T. 1988. Human Biology. Oxford University Press.

Brooker, R.J. 2012. Genetics: analysis & principles. McGraw-Hill Companies, Inc. 4th ed.

Cavalli-Sforza, L.L. and Bodmer, W.F. 1971. The Genetics of Human Population. San Francisco: Freeman.

Crawford, M.H. 2007. Anthropological Genetics Theory, Methods and Applications. Cambridge University Press.

Cummings, M.R. 2011. Human Heredity: Principles and Issues. Ninth Edition. Brooks/Cole, Cengage Learning.

Lewis, R. 2009. Human Genetics: Concepts and Applications 9th Edition. The McGraw−Hill Company, Inc.

Snustad, D.P. and Simmons, M.J. 2006. Principles of Genetics, Fourth Edition. John Wiley & Sons,

Vogel, F. and Motulsky, A.G. 1996. Human Genetics. Springer, 3rd revised edition