Syllabus (CHEMISTRY)

Course Type: MAJ-12

Semester: 7

Course Code: BCEMMAJ12C

Course Title: Inorganic Chemistry – IV

(L-P-Tu): 4-2-0

Credit: 6

Practical/Theory: Combined

Course Objective: COURSE OBJECTIVE OF MAJOR - 12: The syllabus of Major -12 has been designed to provide the students with thorough understanding of the Electron Transport System in Biological Systems, mechanism of Na+ / K+ pumps, photosysthesis process and most important

Learning Outcome: COURSE OUTCOMES OF MAJOR – 12: CO- 12.1 Developing the idea and concepts of Bio-inorganic chemistry. CO- 12.2 Understanding of Organometallic chemistry from Inorganic point of view. CO- 12.3 Study of catalysis by organometallic compounds. CO- 12.4

THEORY:

Bioinorganic Chemistry: (15L)

Elements of life: essential and beneficial elements, major, trace and ultratrace elements. Basic chemical reactions in the biological systems and the role of metal ions (specially Na⁺, K⁺, Mg²⁺, Ca²⁺, Fe³⁺/²⁺, Cu^2+/+, and Zn²⁺). Metal ion transport across biological membrane Na+/ K+-ion pump (Basic Idea). Dioxygen molecule in life. Dioxygen management proteins: Haemoglobin, Myoglobin, Hemocyanine and Hemerythrin.

Electron transfer proteins: Cytochromes and Ferredoxins. Hydrolytic enzymes: carbonate bicarbonate buffering system and carbonic anhydrase and carboxyanhydrase A. Biological nitrogen fixation (Basic Idea).

Photosynthesis: Photosystem-I andPhotosystem-II (Basic Idea). Toxic metal ions and their effects, chelation therapy (examples only), Pt and Au complexes as drugs (examples only), metal dependent diseases (examples only).

ORGANOMETALLIC CHEMISTRY: (10L)

Definition and classification of organometallic compounds on the basis of bond type. Concept of hapticity of organic ligands. 18-electron and 16-electron rules (pictorial MO approach). Applications of 18-electron rule to metal carbonyls, nitrosyls, cyanides. General methods of preparation of mono and binuclear carbonyls of 3d-series. Structures of mononuclear and binuclear carbonyls. Pi-acceptor behaviour of CO, synergic effect and use of IR data to explain extent of back bonding. Zeise’s salt: Preparation, structure, evidences of synergic effect. Ferrocene: Preparation and reactions (acetylation, alkylation, metallation, Mannich Condensation); Applications based on MO diagram of Ferrocene, Structure of Ferrocene.

ORGANOMETALLIC CATALYSIS: (15 L)

1. Alkene hydrogenation (Wilkinson’s Catalyst)

2. Hydroformylation

3. Wacker Process

4. Synthetic gasoline (Fischer Tropsch reaction)

5. Monsanto Acetic Acid Process.

6. Ziegler-Natta catalysis for olefin polymerization.

Reactions of organometallic complexes: substitution, oxidative addition, reductive elimination and insertion reactions.

d & f- BLOCK CHEMISTRY: (20 L)

Transition Elements:

General comparison of 3d, 4d and 5d elements in term of electronic configuration, oxidation states, redox properties, coordination chemistry.

Lanthanoids and Actinoids:

General Comparison on Electronic configuration, oxidation states, colour, spectral andmagnetic properties; lanthanide contraction, separation of lanthanides (ion-exchangemethod only).

READING REFERENCES:

1. Lee, J. D. Concise Inorganic Chemistry ELBS, 1991.
2. Douglas, B.E. and McDaniel, D.H. Concepts & Models of Inorganic Chemistry Oxford, 1970.
3. Atkin, P. Shriver & Atkins’ Inorganic Chemistry 5th Ed. Oxford University Press (2010).
4. Cotton, F.A., Wilkinson, G. and Gaus, P.L., Basic Inorganic Chemistry 3^rd Ed.; Wiley India.
5. Sharpe, A.G., Inorganic Chemistry, 4th Indian Reprint (Pearson Education), 2005.
6. Huheey, J. E.; Keiter, E.A. & Keiter, R.L. Inorganic Chemistry, Principles of Structure andReactivity 4th Ed., Harper Collins 1993, Pearson,2006.
7. Das, Asim. K.; Fundamentals Concepts of Inorganic Chemistry, Vol 1-7, 3^rd Ed., CBS Publishers.
8. Miessler, G. L., Fischer, P. J., Tarr, D. A., Inorganic Chemistry, Pearson, 5th Edition.
9. Lippard, S.J. & Berg, J.M. Principles of Bioinorganic Chemistry Panima Publishing Company 1994.
10. Bertini, I., Gray, H. B., Lippard, S.J., Valentine, J. S., Viva, 2007.
11. Basolo, F, and Pearson, R.C. Mechanisms of Inorganic Chemistry, John Wiley & Sons, NY, 1967.
12. Powell, P. Principles of Organometallic Chemistry, Chapman and Hall, 1988.
13. Collman, J. P. et al. Principles and Applications of Organotransition Metal Chemistry. Mill Valley, CA: University Science Books, 1987.
14. Crabtree, R. H. The Organometallic Chemistry of the Transition Metals. New York, NY: JohnWiley, 2000.

PRACTICALS:

Qualitative semi-micro analysis

Qualitative semimicro analysis of mixtures containing four radicals. Emphasis should be given to the understanding of the chemistry of different reactions and to assign the most probable composition.

Cation Radicals: Na⁺, K⁺, Ca²⁺, Sr²⁺, Ba²⁺, Al³⁺, Cr³⁺, Mn²⁺/Mn⁴⁺, Fe³⁺,Co²⁺/Co³⁺, Ni²⁺, Cu²⁺, Zn²⁺, Pb²⁺, Cd²⁺, Bi³⁺, Sn²⁺/Sn⁴⁺, As³⁺/As⁵⁺, Sb³⁺/⁵⁺, NH⁴⁺, Mg²⁺.

Anion Radicals: F^-, Cl^-, Br^-, BrO₃^-, I^-, IO₃^-, SCN^-, S^2-, SO₄^2-, NO₃^-, NO₂^-, PO₄^3- , AsO₄^3-, BO₃^3-, CrO₄^2- / Cr₂O₇^2-, [Fe(CN)₆]^4-, [Fe(CN)₆]^3-.

Insoluble Materials: Al₂O₃(ig), Fe₂O₃(ig), Cr₂O₃(ig), SnO₂, SrSO₄, BaSO₄, CaF₂, PbSO₄.

REFERENCES FOR PRACTICALS:

1. Svehla, G., Vogel’s Qualitative Inorganic Analysis, Pearson Education, 2012.
2. Mukherjee, G. N., Semi-Micro Qualitative Inorganic Analysis, University of Calcutta, 2008.

3. Bhattacharya, R. C., A Manual of Practical Chemistry for degree classes (Vol. I & II) for Honours Students, Biswas Book Stall, Calcutta.