Sidho-Kanho-Birsha University
Syllabus & Course Curriculam
Syllabus & Course Curriculam
Course Type: MAJ-18
Semester: 8
Course Code: BZOOMAJ18C
Course Title: Clinical Immunology and Infection Biology
(L-P-Tu): 4-2-0
Credit: 6
Practical/Theory: Combined
Course Objective:
Learning Outcome: Course Outcome: After completion of this elective, student will understand the fundamentals of molecular mechanism behind immunity. They will have a wide knowledge of many immunological techniques that include immunohistochemistry, ELISA, FACS etc. They w
Clinical Immunology and Infection Biology
Theory=4 credits
Clinical Immunology and Infection Biology
Course Objective: This topic gives emphasis on the advanced immunological aspects including treatments related to immunity. The students will be able to understand the theoretical framework about the complex molecular mechanisms involved in the immunity and the related immunological methods. Along with these the students will be able to understand about tolerance, immunodeficiency and vaccination, immunology of transplantation, the immunology of tumors, immunomodulation, and immunopharmacology.
Major Histocompatibility Complex
Structure and functions of MHC molecules.
Structure of T cell Receptor and its signalling, T cell development & selection
Cytokines
Types, properties and functions of cytokines.
Complement System
Components and pathways of complement activation.
Hypersensitivity
Gell and Coombs’ classification and brief description of various types of hypersensitivities.
Immunologic Tolerance and Autoimmunity
Autoimmune disorders – Rheumatoid arthritis, Systemic lupus erythematosus, Inflammatory bowel disease
Immunity to Tumors
Tumour microenvironment and immune cells- TAM, T reg cells and others, Immune check point inhibitors
Transplantation Immunology
Different types grafting, Graft rejection, Graft versus host disease (GvHD),Genetics of HLA typing and disease association
Immune Response to Infectious Diseases
Mechanism of Immune Response During: Viral Infections [Influenza, HIV, corona virus, Adenovirus], Bacterial Infections [Corynebacteria and Mycobacterium] Protozoan Infection [Plasmodium, Trypanosoma and Leishmania], Helminthes Infections [Ascaris and Schistosoma].
Immunotechnology
Vaccine – different types of vaccine, strategies of vaccine development - subunit vaccine, mRNA vaccine and others, Hybridoma technology, Antibody engineering Immunoassays- Types and applications, Immunophenotyping,
Principle, Methodology and Application of Following Techniques: ELISA [Enzyme Linked Immunosorbent Assay], RIA [Radio Immuno Assay], Western Blotting. Allergy Evaluation: Principle and Methodology of Skin Prick Test for Allergy.
Practical 2 credits
Trypanosoma, Leishmania sp, (Promastigote and amastigote), Opalina sp., Nyctotherus, Sicuophora, Balantidium, Stomatophora, Monocystis, Giardia, Entamoeba histolytica, Gregarina, Eimeria, Haemoproteus, Plasmodium (vivax & falciparum species), Conchophthirus, Myxobolus, Taenia solium, Taenia saginata, Raillietina sp., (mature proglottid and scolex), Echinococcus, Fasciola, Isoparorchis, Paramphistomum, Ascaris (male and female), Argulus, Pediculus, Phthirus, Cimax, Xenopsylla, Ctenocephalids, Boophilus, Phlebotomus, mosquitoes (adult male & female, mouth parts of Anopheles, Culex, and Aedes)
Laboratory Note Book must be prepared on day-to-day basis and should be signed by the concerned teacher immediately after the laboratory work. The Laboratory Note Book should contain all the items in the syllabus and must be submitted on the day of examination.
Reference Books:
Basic Features
Undergraduate degree programmes of either 3 or 4-year duration, with multiple entry and exit points and re-entry options, with appropriate certifications such as:
Note: The eligibility condition of doing the UG degree (Honours with Research) is- minimum75% marks to be obtained in the first six semesters.
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